// STRESS & RECOVERY
Stress & Recovery
HPA axis, cortisol regulation, sympathetic/parasympathetic balance
Acute stress is adaptive — cortisol mobilizes energy and sharpens focus. But the HPA axis was designed for brief threats, not chronic activation. When the hypothalamus continuously releases CRH, and the adrenals overproduce cortisol, the negative feedback loop breaks down. The result: immune suppression, hippocampal atrophy, and insulin resistance.
Mechanism
14%
hippocampal volume reduction from chronic elevated cortisol over a decade — stress literally shrinks your brain
Lupien et al., Nature Reviews Neuroscience 2009