Your gut wall is a single cell layer thick — the only barrier between your microbiome and your bloodstream. When tight junctions break down (intestinal permeability), bacterial endotoxins like LPS enter circulation, triggering systemic inflammation that affects the brain, skin, metabolism, and immune function.
Mechanism
70-80%
of your immune cells reside in the gut-associated lymphoid tissue (GALT) — your gut is your largest immune organ
Vighi et al., Clinical & Experimental Immunology 2008
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